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1

Relationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2′-deoxyuridines

Isabelle Creuven, Christine Evrard, Anne Olivier, Guy Evrard, Arthur Van Aerschot, Piet Wigerinck, Piet Herdewijn, Francois Durant

Journal:

Antiviral Research

Année:

1996

Langue:

english

Fichier:

PDF, 643 KB

english, 1996

2

Powder for reconstitution of the anti-HIV-1 drug TMC278 – Formulation development, stability and animal studies

Elke Van Gyseghem, Murali Pendela, Lieven Baert, Jan Rosier, Gerben Van ’t Klooster, Hilde De Man, Marie-Paule Bouche, Laurent Schueller, Pieter Van Remoortere, Piet Wigerinck, Erwin Adams, Jos Hoogma

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2008

Langue:

english

Fichier:

PDF, 236 KB

english, 2008

3

Design and Optimization of Tricyclic Phtalimide Analogues as Novel Inhibitors of HIV-1 Integrase

Verschueren, Wim G., Dierynck, Inge, Amssoms, Katie I. E., Hu, Lili, Boonants, Paul M. J. G., Pille, Geert M. E., Daeyaert, Frits F. D., Hertogs, Kurt, Surleraux, Dominique L. N. G., Wigerinck, Piet B

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 322 KB

english, 2005

4

Synthesis of 8-Mercapto-2′,3′-Dideoxyadenosine and 8-Mercapto-2′,3′-Dideoxyinosine

P. Herdewijn, A. van Aerschot, P. Wigerinck, L. Kerremans

Journal:

Bulletin des Sociétés Chimiques Belges

Année:

1991

Langue:

english

Fichier:

PDF, 76 KB

english, 1991

5

Synthesis and HPLC-purification of [77Br]TMC125-R165335 (etravirine), a new anti-HIV drug of the DAPY-NNRTI class

Bart De Spiegeleer, Filip Dumont, Kathelijne Peremans, Christian Burvenich, Lieven Van Vooren, Jan Rosier, Lieven Baert, Piet Wigerinck, Guido Slegers

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2006

Langue:

english

Fichier:

PDF, 123 KB

english, 2006

6

Influence of labeling conditions on the relative amounts of the diastereomers of 99mTc mercaptoacetylglycylalanylglycine (99mTc-MAGAG)

B. Cleynhens, P. Wigerinck, G. Bormans, M. De Roo, A. Verbruggen

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1989

Langue:

english

Fichier:

PDF, 141 KB

english, 1989

7

Dog model with implanted pump to test boosters for antiretroviral medication

Laurent Schueller, Lieven Baert, Sophie Lachau-Durand, Herman Borghys, Ellen Clessens, Guy Van Den Mooter, Elke Van Gyseghem, Tim H.M. Jonckers, Pieter Van Remoortere, Piet Wigerinck, Jan Rosier

Journal:

International Journal of Pharmaceutics

Année:

2008

Langue:

english

Fichier:

PDF, 467 KB

english, 2008

8

Development of an implantable infusion pump for sustained anti-HIV drug administration

Lieven Baert, Laurent Schueller, Yanik Tardy, Doug Macbride, Gerben van’t Klooster, Herman Borghys, Ellen Clessens, Guy Van Den Mooter, Elke Van Gyseghem, Pieter Van Remoortere, Piet Wigerinck, Jan Ro

Journal:

International Journal of Pharmaceutics

Année:

2008

Langue:

english

Fichier:

PDF, 534 KB

english, 2008

9

Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors

Pierre Raboisson, Tse-I Lin, Herman de Kock, Sandrine Vendeville, Wim Van de Vreken, David McGowan, Abdellah Tahri, Lili Hu, Oliver Lenz, Frederic Delouvroy, Dominique Surleraux, Piet Wigerinck, Magnu

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 233 KB

english, 2008

10

Dimeric building blocks with N-cyanoguanidine linkage for oligonucleotide synthesis

C. Pannecouque, P. Wigerinck, A. Van Aerschot, P. Herdewijn

Journal:

Tetrahedron Letters

Année:

1992

Langue:

english

Fichier:

PDF, 118 KB

english, 1992

11

Synthesis of thymidine from 5-iodo-2′-deoxyuridine

P. Herdewijn, L. Kerremans, P. Wigerinck, F. Vandendriessche, A. Van Aerschot

Journal:

Tetrahedron Letters

Année:

1991

Langue:

english

Fichier:

PDF, 206 KB

english, 1991

12

5-(thien-2-yl) uracil analogs: 5-(5-methylthien-2-yl)-2′-deoxyuridine, 5-(5-thien-2-yl)-2′-deoxyuridine, and 5-(5-bromothien-2-yl)-2′-deoxyuridine

Isabelle Creuven, Bernadette Norberg, Anne Olivier, Christine Evrard, Guy Evrard, Piet Wigerinck, Piet Herdewijn, François Durant

Journal:

Journal of Chemical Crystallography

Année:

1996

Langue:

english

Fichier:

PDF, 639 KB

english, 1996

13

Abstracts of oral presentations

R. Boulieu, A. Lenoir, J. F. Mornex, C. Bohman, J. Balzarini, P. Wigerinck, A. Van Aerschot, P. Herdewijn, Erik De Clercq, S. Brosh, E. Zoref-Shani, O. Sperling, E. Danziger, Y. Sidi, Y. Bromberg, Ren

Journal:

International Journal of Clinical Pharmacy

Année:

1993

Langue:

english

Fichier:

PDF, 1.03 MB

english, 1993

14

3′-(1,2,3-Triazol-1-yl)-2′,3′-dideoxythymidine and 3′-(1,2,3-triazol-1-yl)-2′,3′-dideoxyuridine

Piet Wigerinck, Arthur Van Aerschot, Paul Claes, Jan Balzarini, Erik De Clercq, Piet Herdewijn

Journal:

Journal of Heterocyclic Chemistry

Année:

1989

Fichier:

PDF, 668 KB

1989

15

Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines

Wigerinck, Piet, Van Aerschot, Arthur, Janssen, Gerard, Claes, Paul, Balzarini, Jan, De Clercq, Erik, Herdewijn, Piet

Journal:

Journal of Medicinal Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 821 KB

english, 1990

16

GLPG0187 inhibits progression of established bone metastasis and achieves maximum efficacy when combined with standard-of-care metastatic breast cancer treatments

P. Clément-Lacroix, E. Berrocal, B. Heckmann, P. Wigerinck, G. Lorenzon, P. Pujuguet*

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 55 KB

english, 2011

17

PP 87 Molecular imaging demonstrates GLPG0187, a small-molecule integrin antagonist, binds to RGD-integrin receptors in vivo and is efficacious in tumor and metastasis models

P. Pujuguet, E. Berrocal, B. Heckmann, P. Wigerinck, G. Lorenzon, P. Clément-Lacroix, G. Bormans, C. Deroose

Journal:

European Journal of Cancer

Année:

2011

Langue:

english

Fichier:

PDF, 55 KB

english, 2011

18

Stereoselective and Efficient Synthesis of (3 R ,3a S ,6a R )-Hexahydrofuro[2,3- b ]furan-3-ol

Quaedflieg, Peter J. L. M., Kesteleyn, Bart R. R., Wigerinck, Piet B. T. P., Goyvaerts, Nicolaas M. F., Vijn, Robert Jan, Liebregts, Constantinus S. M., Kooistra, Jaap H. M. H., Cusan, Claudia

Journal:

Organic Letters

Année:

2005

Langue:

english

Fichier:

PDF, 65 KB

english, 2005

19

Stereoelectronic properties of five anti-HSV-1 2′-deoxynucleosides analogues with heterocyclic substituents in the 5-position: A comparison with BVDU

Anne Olivier, Isabelle Creuven, Christine Evrard, Guy Evrard, Magdalena Dory, Arthur van Aerschot, Piet Wigerinck, Piet Herdewijn, François Durant

Journal:

Antiviral Research

Année:

1994

Langue:

english

Fichier:

PDF, 733 KB

english, 1994

20

Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogs

Wigerinck, Piet, Kerremans, Luc, Claes, Paul, Snoeck, Robert, Maudgal, Prabhat, De Clercq, Erik, Herdewijn, Piet

Journal:

Journal of Medicinal Chemistry

Année:

1993

Langue:

english

Fichier:

PDF, 854 KB

english, 1993

21

Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines

Wigerinck, P., Snoeck, R., Claes, P., De Clercq, E., Herdewijn, P.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 848 KB

english, 1991

22

5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication

Wigerinck, P., Pannecouque, C., Snoeck, R., Claes, P., De Clercq, E., Herdewijn, P.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.03 MB

english, 1991

23

Synthesis of 3?-fluoromethylthio-, 3?-fluoromethylsulfinyl- and 3?-fluoromethylsulfonyl-substituted 3?-deoxythymidine

Herdewijn, Piet, De Bruyn, Andr�, Wigerinck, Piet, Hendrix, Chris, Kerremans, Luk, Rozenski, Jef, Busson, Roger

Journal:

Journal of the Chemical Society Perkin Transactions 1

Année:

1994

Langue:

english

Fichier:

PDF, 1011 KB

english, 1994

24

Synthesis of Thymidine Analogues with a Cyanoimido Substituent

Wigerinck, P., Van Aerschot, A., Kerremans, L., Balzarini, J., De Clercq, E., Claes, P., Herdewijn, P.

Journal:

Nucleosides and Nucleotides

Année:

1991

Langue:

english

Fichier:

PDF, 104 KB

english, 1991

25

In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

Lin, T.-I, Lenz, O., Fanning, G., Verbinnen, T., Delouvroy, F., Scholliers, A., Vermeiren, K., Rosenquist, A., Edlund, M., Samuelsson, B., Vrang, L., de Kock, H., Wigerinck, P., Raboisson, P., Simmen,

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2009

Langue:

english

Fichier:

PDF, 390 KB

english, 2009

26

Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2'-Deoxyuridine

Liu, J., Van Aerschot, A., Luyten, I., Wigerinck, P., Pannecouque, C., Balzarini, J., De Clercq, E., Herdewijn, P.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Année:

1995

Langue:

english

Fichier:

PDF, 195 KB

english, 1995

27

Oral administration of GLPG0259, an inhibitor of MAPKAPK5, a new target for the treatment of rheumatoid arthritis: a phase II, randomised, double-blind, placebo-controlled, multicentre trial

Westhovens, R., Keyser, F. D., Rekalov, D., Nasonov, E. L., Beetens, J., Van der Aa, A., Wigerinck, P., Namour, F., Vanhoutte, F., Durez, P.

Journal:

Annals of the Rheumatic Diseases

Année:

2013

Langue:

english

Fichier:

PDF, 226 KB

english, 2013

28

5-(Thien-2-yl)-2′-deoxyuridine: A New and Potent Inhibitor of Herpes Simplex Virus Type 1 Replication

Wigerinck, P., Van Aerschot, A., De Clercq, E., Herdewijn, P.

Journal:

Nucleosides and Nucleotides

Année:

1991

Langue:

english

Fichier:

PDF, 104 KB

english, 1991

29

Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action

Jochmans, D., Deval, J., Kesteleyn, B., Van Marck, H., Bettens, E., De Baere, I., Dehertogh, P., Ivens, T., Van Ginderen, M., Van Schoubroeck, B., Ehteshami, M., Wigerinck, P., Gotte, M., Hertogs, K.

Journal:

Journal of Virology

Année:

2006

Langue:

english

Fichier:

PDF, 788 KB

english, 2006

30

Cost effectiveness of treatment for gastro-oesophageal reflux disease in clinical practice: a clinical database analysis

Eggleston, A, Wigerinck, A, Huijghebaert, S, Dubois, D, Haycox, A

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 136 KB

english, 1998

31

TMC114, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor Active against Protease Inhibitor-Resistant Viruses, Including a Broad Range of Clinical Isolates

De Meyer, S., Azijn, H., Surleraux, D., Jochmans, D., Tahri, A., Pauwels, R., Wigerinck, P., de Bethune, M.-P.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2005

Langue:

english

Fichier:

PDF, 324 KB

english, 2005

32

2'-Deoxyuridines with a 5-Heteroaromatic Substituent: Synthesis and Biological Evaluation

Luyten, I., Jie, L., Van Aerschot, A., Pannecouque, C., Wigerinck, P., Rozenski, J., Hendrix, C., Wang, C., Wiebe, L., Balzarini, J., De Clercq, E., Herdewijn, P.

Journal:

Antiviral Chemistry & Chemotherapy

Année:

1995

Langue:

english

Fichier:

PDF, 477 KB

english, 1995

33

Structural and Thermodynamic Basis for the Binding of TMC114, a Next-Generation Human Immunodeficiency Virus Type 1 Protease Inhibitor

King, N. M., Prabu-Jeyabalan, M., Nalivaika, E. A., Wigerinck, P., de Bethune, M.-P., Schiffer, C. A.

Journal:

Journal of Virology

Année:

2004

Langue:

english

Fichier:

PDF, 945 KB

english, 2004

34

Sugar and Base-Modified 2',3'-Dideoxynucleosides as Potential Anti-Aids Drugs

Van Aerschot, Arthur, Balzarini, Jan, Pauwels, Rudi, Wigerinck, Piet, De Clercq, Erik, Herdewijn, Piet

Journal:

Nucleosides Nucleotides & Nucleic Acids

Année:

1989

Langue:

english

Fichier:

PDF, 236 KB

english, 1989

35

ChemInform Abstract: Synthesis and Antiviral Activity of 3′-Heterocyclic Substituted 3′-Deoxythymidines.

WIGERINCK, P., VAN AERSCHOT, A., JANSSEN, G., CLAES, P., BALZARINI, J., DE CLERCQ, E., HERDEWIJN, P.

Journal:

Année:

1990

Fichier:

PDF, 210 KB

1990

36

ChemInform Abstract: 3′-(1,2,3-Triazol-1-yl)-2′,3′-dideoxythymidine and 3′-(1,2,3-Triazol-1-yl)-2′,3′-dideoxyuridine.

WIGERINCK, P., VAN AERSCHOT, A., CLAES, P., BALZARINI, J., DE CLERCQ, E., HERDEWIJN, P.

Journal:

Année:

1990

Fichier:

PDF, 120 KB

1990

37

Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus

Bohman, Christina, Baizarini, Jan, Wigerinck, Piet, {Van Aerschot}, Arthur, Herdewijn, Piet, {De Clercq}, Erik

Journal:

Journal of Biological Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 904 KB

english, 1994

38

THU0236 Once-Daily Dosing of GLPG0634, a Selective JAK1 Inhibitor, is Supported by Its Active Metabolite

Namour, F., Galien, R., Vanhoutte, F. P., Wigerinck, P., van ’t Klooster, G.

Journal:

Annals of the Rheumatic Diseases

Année:

2013

Langue:

english

Fichier:

PDF, 404 KB

english, 2013

39

OP0263 Efficacy and safety of GLPG0634, a selective JAK1 inhibitor, after short-term treatment of rheumatoid arthritis; results of a phase IIA trial

Vanhoutte, F.P., Mazur, M., Namour, F., van der Aa, A., Wigerinck, P., van ’t Klooster, G.A.E.

Journal:

Annals of the Rheumatic Diseases

Année:

2013

Langue:

english

Fichier:

PDF, 61 KB

english, 2013

40

Treatment innovation for patients: a collaborative network in the Benelux and an inside view of 20 years of Galapagos

Durez, Patrick, Hoekema, AndrÃ©, Huizinga, Tom, Gazin, Muriel, Present, Erik, Veelaert, Dirk, Wigerinck, Piet, Westhovens, RenÃ©

Journal:

Acta Clinica Belgica

Année:

2020

Fichier:

PDF, 784 KB

2020